Paulo Dybala scored twice as Juventus took charge of their Champions League quarter-final tie with Barcelona courtesy of a commanding home-leg display in Turin.
The Argentine forward curled home both of his goals before the break, the first from an angle inside the box and the second from a central position on the edge.
Juve turned a dominant lead into one that should see them go on and win the tie when Giorgio Chiellini showed strength and guile to steer home a header from a corner.
For the second European round running, Barca - who were as defensively suspect as they were in losing 4-0 to Paris St-Germain in the first leg of their last-16 tie - must come back from a heavy away defeat to progress.
However, after their record-breaking achievement to overturn that deficit against PSG, they will retain hope heading into the return leg at the Nou Camp on 19 April.
The last time these two sides met in the Champions League was in the 2015 final, when Barcelona secured the trophy courtesy of a 3-1 win.
The Italians are a much-changed side, with only goalkeeper Gianluigi Buffon and defender Leonardo Bonucci starting both the game in Berlin and Tuesday's in Turin, but they played like a side with a score to settle.
The opening 20 minutes were a lesson in high-pressing, aggressive play that created a clear headed opening for Gonzalo Higuain to spurn before paying off through Dybala's two strikes.
The remaining 70 minutes saw Juve retain a high work-rate but with the luxury of strategically selecting their moments to counter attack.
This approach twice set up Higuain for shots that were saved by Marc-Andre ter Stegen before more lax defending - this time from Javier Mascherano, who had been moved to centre-back from midfield at half-time - allowed Chiellini to head home from a corner.
The win means Juve, who have won their last 32 Serie A home games, are now undefeated in 18 European games in Turin.
With the second-best defence of any side in Europe's top-five leagues and having gone 441 Champions League minutes without conceding, the Italians are well-equipped to avoid wilting under second-leg pressure in Spain.