Defending champions Real Madrid will face Bayern Munich in the semi-finals of the Champions League while Liverpool play AS Roma in a repeat of the 1984 final.
Cristiano Ronaldo's Real will travel to Bayern's Allianz Arena for the first leg on April 25 as the Spanish giants go in search of a third successive European crown.
Jurgen Klopp's Liverpool side will host Roma at Anfield on April 24 in their first match.
The Liverpool-Roma tie pits Mohamed Salah, who has scored 39 goals in all competitions already this season, against his former club. "Looking forward to seeing you again," Roma tweeted about the Egyptian striker.
Real, who have won the competition 12 times, reached the semi-finals by fighting off a remarkable Juventus comeback as Ronaldo scored a late penalty to earn a 4-3 win on aggregate.
- Remarkable comeback -
Roma produced one of the most remarkable comebacks in Champions League history to knock out Lionel Messi's Barcelona with a 3-0 victory in the Italian capital that gave them an unexpected win on away goals over the two legs.
Bundesliga champions Bayern, who named their former player Niko Kovac as their next coach minutes before the draw, eased past Sevilla in their quarter-final.
Bayern's sporting director Hasan Salihamidzic said despite losing to Real in the 2017 quarter-finals, they held no fear for the Bavarians.
"They are formidable opponents.We were knocked out by them last year and we want to do better this year," Salihamidzic said.
"I'm optimistic. We have great respect for them but we're not afraid."
Real director Emilio Butragueno said Zinedine Zidane's team were confident they can win a third consecutive European crown.